Substances
Semax
Across 192 answers, 11% gave the top answer (a 10/10 or “changed my life”) and 70% said it helped a lot or more.
All answers · 192 answers
- Life-changing
- Big help
- Slight help
- Did nothing
- Made it worse
Have you tried it?
Only answer if you've tried Semax. What did it do for you?
What is it?
Semax is a synthetic peptide, a short amino-acid chain developed in Russia. It has been used there for neurological conditions, including stroke. Online sellers mainly offer nasal products, sought out for concentration, studying and mental fatigue.
Research involving brain injury does not establish a performance benefit for healthy users. Changes in neuron-related signals in an experiment also cannot substantiate promises of better learning or long-term brain protection.
All answers
192 answers in total: 190 from surveys and 2 from this site.
- Life-changing: 11%, 21 votes
- Big help: 59%, 114 votes
- Slight help: 20%, 39 votes
- Did nothing: 9.4%, 18 votes
- Made it worse: 0%, 0 of 68 answers
By questionnaire
On this site · 2 answers
Surveys with all five answers · 66 answers from Nootroflix (2022)
Surveys without “made it worse” · 124 answers from the SlateStarCodex 2016 nootropics survey
- Life-changing
- Big help
- Slight help
- Did nothing
- Made it worse
Survey answers are converted to these five answers. Each share above counts only the questionnaires that offered that answer, because not every survey offered all five. In Nootroflix (2022) and the SlateStarCodex 2016 nootropics survey, a 10 out of 10 rating counts as “changed my life”.
What does it feel like?
There is no reliable description of what you should feel when using it for focus. Reports of clarity or motivation cannot predict your experience or separate a product effect from expectations.
Feeling no discomfort is not a safety test. Studies do not adequately characterize adverse effects, and feeling fine today cannot settle the risks of months of use.
What are the risks?
FDA reviewers flag potential immune reactions related to peptide impurities or aggregation. They also raise a possible bleeding concern, particularly with medicines that increase bleeding risk. These concerns remain poorly studied, and interactions are not fully characterized.
Nasal and injectable products cannot be treated as equally safe because they share a name. Human safety data for subcutaneous injection are lacking. Semax is not an FDA-approved medicine; shipping availability does not establish local authorization. A “research only” label does not validate a product for home use.
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Semax ranks #11 of 24 in Substances for life-changing.
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- 11SemaxThis pageA synthetic peptide used in Russia for stroke, sold online as a nasal spray for focus. How people who took it rate it, from made things worse to life-changing.10%192 votes
Know someone who's tried Semax?
Every answer makes this page more accurate. Share it with people who've tried Semax, whether it changed their life or did nothing for them.
Self-reported experiences, not medical advice. High scores mean people reported strong positive effects. They do not mean something is safe, effective long-term, or appropriate for you. Self-reports can miss delayed harms, dependence, withdrawal, side effects, and selection bias. Don't start or stop a medication because of a chart.
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