SSRIs (Prozac, Lexapro…)

SSRIs are antidepressants including fluoxetine, sertraline and escitalopram. They are prescribed for depression and, depending on the medicine, certain anxiety and obsessive-compulsive conditions. The name describes their action on serotonin; it doesn't tell you which one suits you or how taking it will feel.

A friend's experience doesn't make these medicines interchangeable. Follow-up takes time and should include sleep, sexual function and everyday life. Reporting something unpleasant is part of treatment, not a complaint you're supposed to keep to yourself.

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Nausea, sleep changes, restlessness or fatigue can occur. Sexual desire and the ability to orgasm may change too. Some people describe feeling emotionally muted, while others don't experience that.

An unwanted effect may be noticeable before you have a clear picture of the treatment overall. Neither an immediate sensation nor its absence tells you what decision to make alone. New thoughts of self-harm or severe agitation need prompt medical attention.

These are prescription medicines with important interactions. Other serotonin-affecting drugs or supplements can cause serious serotonin syndrome, and some combinations increase bleeding risk. Worsening mood, suicidal thoughts or unusual excitement need attention, particularly when starting or changing treatment.

Compulsive pursuit of a high isn't typical, but physical dependence and withdrawal can occur, with dizziness, insomnia or electric-shock sensations. Stopping needs a plan with the prescriber; withdrawal can be prolonged and difficult. Sexual problems continuing after discontinuation have also been reported.